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GPIIb/IIIa autoantibody predicts better rituximab response in ITP.

Authors :
Feng, Rui
Liu, Xinguang
Zhao, Yajing
Zhu, Yuanyuan
Peng, Jun
Hou, Ming
Chen, Chunyan
Source :
British Journal of Haematology; Jul2018, Vol. 182 Issue 2, p305-307, 3p, 1 Chart, 1 Graph
Publication Year :
2018

Abstract

The article discusses the relationship between antibody specificities and efficacy of rituximab in patients with primary immune thrombocytopenia (ITP). The authors discovered that patients with anti-GPIIb/IIIa autoantibodies responded more to rituximab therapy. Autoantibody specificity was found before rituximab therapy using modified monoclonal antibody immobilization of platelet antigen assay.

Details

Language :
English
ISSN :
00071048
Volume :
182
Issue :
2
Database :
Complementary Index
Journal :
British Journal of Haematology
Publication Type :
Academic Journal
Accession number :
130603707
Full Text :
https://doi.org/10.1111/bjh.14782