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The Time Point-Specific Effect of Beta-Adrenergic Blockade in Attenuating High Fat Diet-Induced Obesity and Bone Loss.
- Source :
- Calcified Tissue International; Aug2018, Vol. 103 Issue 2, p217-226, 10p
- Publication Year :
- 2018
-
Abstract
- We aimed to clarify the key factor determining the effect of beta blocker attenuating high fat diet- induced obesity and bone loss. Six-week-old C57BL/6 male mice were assigned to groups reflecting different relative onset of obesity and beta blocker administration, different diet (control vs. high fat), and treatment (vehicle vs. beta blocker: propranolol). Mice in Group 1 were fed a control diet (CON) or high fat diet (HIGH) with vehicle or propranolol for 12 weeks. Mice in Group 2 were fed a CON or HIGH without pharmaceutical treatment for the first 12 weeks, followed by another 12 weeks of treatment with vehicle or propranolol. Mice in Group 3 were fed a CON without pharmaceutical treatment for the first 12 weeks, followed by stratification into diet-based subgroups and another 12 weeks of treatment with vehicle or propranolol. Propranolol attenuated the HIGH-induced increase in body weight/fat mass in Group 1 mice and in Group 3 mice, but not in Group 2 mice. Propranolol mitigated HIGH-induced reduction in femoral trabecular bone mineral density and bone architecture deterioration in Group 1 mice but not in Group 2 mice. HIGH feeding in Group 3 did not compromise skeletal integrity. Taken together, propranolol attenuates HIGH-induced body weight increases while weight gain is in progress but not once obesity has already been established. HIGH feeding during the growth period results in compromised bone mass/architecture; which can be attenuated by propranolol administration during the growth period, but not by propranolol administration after obesity has already been established. [ABSTRACT FROM AUTHOR]
- Subjects :
- OBESITY treatment
HIGH-fat diet
ADRENERGIC beta blockers
DRUG administration
PROPRANOLOL
THERAPEUTICS
ANIMAL experimentation
BODY weight
BONES
CELLULAR signal transduction
COMPARATIVE studies
DIET
RESEARCH methodology
MEDICAL cooperation
MICE
OBESITY
OSTEOPENIA
RESEARCH
RESEARCH funding
TIBIA
EVALUATION research
BONE density
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 0171967X
- Volume :
- 103
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Calcified Tissue International
- Publication Type :
- Academic Journal
- Accession number :
- 130646019
- Full Text :
- https://doi.org/10.1007/s00223-018-0407-3