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A bidirectional relationship between sleep and oxidative stress in Drosophila.
- Source :
- PLoS Biology; 7/12/2018, Vol. 16 Issue 7, p1-22, 22p, 6 Graphs
- Publication Year :
- 2018
-
Abstract
- Although sleep appears to be broadly conserved in animals, the physiological functions of sleep remain unclear. In this study, we sought to identify a physiological defect common to a diverse group of short-sleeping Drosophila mutants, which might provide insight into the function and regulation of sleep. We found that these short-sleeping mutants share a common phenotype of sensitivity to acute oxidative stress, exhibiting shorter survival times than controls. We further showed that increasing sleep in wild-type flies using genetic or pharmacological approaches increases survival after oxidative challenge. Moreover, reducing oxidative stress in the neurons of wild-type flies by overexpression of antioxidant genes reduces the amount of sleep. Together, these results support the hypothesis that a key function of sleep is to defend against oxidative stress and also point to a reciprocal role for reactive oxygen species (ROS) in neurons in the regulation of sleep. [ABSTRACT FROM AUTHOR]
- Subjects :
- SLEEP disorders
CIRCADIAN rhythms
SLEEP-wake cycle
OXIDATIVE stress
DROSOPHILA
Subjects
Details
- Language :
- English
- ISSN :
- 15449173
- Volume :
- 16
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- PLoS Biology
- Publication Type :
- Academic Journal
- Accession number :
- 130650826
- Full Text :
- https://doi.org/10.1371/journal.pbio.2005206