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A pilot study to profile salivary angiogenic factors to detect head and neck cancers.

Authors :
van der Merwe, L.
Wan, Y.
Cheong, H. J.
Perry, C.
Punyadeera, C.
Source :
BMC Cancer; 7/13/2018, Vol. 18 Issue 1, p1-8, 8p, 1 Black and White Photograph, 1 Chart, 3 Graphs
Publication Year :
2018

Abstract

<bold>Background: </bold>Early diagnosis of head and neck squamous cell carcinoma (HNSCCs) is an appealing way to increase survival rates in these patients as well as to improve quality of life post-surgery. Angiogenesis is a hallmark of tumor initiation and progression. We have investigated a panel of angiogenic factors in saliva samples collected from HNSCC patients and controls using the Bio-Plex ProTM assays.<bold>Methods: </bold>We have identified a panel of five angiogenic proteins (sEGFR, HGF, sHER2, sIL-6Ra and PECAM-1) to be elevated in the saliva samples collected from HNSCC patients (n = 58) compared to a control cohort (n = 8 smokers and n = 30 non-smokers).<bold>Results: </bold>High positive correlations were observed between the following sets of salivary proteins; sEGFR:sHER2, sEGFR:HGF, sEGFR:sIL-6Rα, sHER2:HGF and sHER2:sIL6Ra. A moderate positive correlation was seen between FGF-basic and sEGFR.<bold>Conclusion: </bold>We have shown that angiogenic factor levels in saliva can be used as a potential diagnostic biomarker panel in HNSCC. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14712407
Volume :
18
Issue :
1
Database :
Complementary Index
Journal :
BMC Cancer
Publication Type :
Academic Journal
Accession number :
130660199
Full Text :
https://doi.org/10.1186/s12885-018-4656-3