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High MMP-26 expression in glioma is correlated with poor clinical outcome of patients.
- Source :
- Oncology Letters; Aug2018, Vol. 16 Issue 2, p2237-2242, 6p
- Publication Year :
- 2018
-
Abstract
- To date the management of glioma remains a great challenge in cancer therapy worldwide. The identification of novel diagnostic and therapeutic methods is required. Although there is data indicating that matrix metalloproteinase (MMP)-26 serves an important role in many human cancer types, its clinical significance in glioma remains uncertain. The present study aimed to evaluate MMP-26 expression in human astrocytic glioma specimens, and investigate its role and significance in the progression of astrocytic glioma. Immunohistochemistry was performed to assess MMP-26 expression in astrocytic glioma tissues. The levels of MMP-26 expression and its relevance to the clinicopathological features and prognostic factors in patients with astrocytic glioma patients were then investigated. The results demonstrated that MMP-26 expression was significantly assocaited with the World Health Organization grade (P<0.05). Additionally, it was identified that MMP-26 expression was an effective predictor of the overall survival of patients with astrocytic glioma (P<0.05). Analyses of univariate and multivariate Cox regression confirmed that MMP-26 expression was an independent factor for evaluating the prognosis of astrocytic glioma patients (P<0.05). The current results support that MMP-26 may be a novel indicator of diagnosis and an independent factor for evaluating prognosis in patients with glioma. [ABSTRACT FROM AUTHOR]
- Subjects :
- MATRIX metalloproteinases
GLIOMAS
IMMUNOHISTOCHEMISTRY
NEOVASCULARIZATION
METASTASIS
Subjects
Details
- Language :
- English
- ISSN :
- 17921074
- Volume :
- 16
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Oncology Letters
- Publication Type :
- Academic Journal
- Accession number :
- 130698007
- Full Text :
- https://doi.org/10.3892/ol.2018.8880