Application of ESI-HRMS method in analysis of the synthesis process of catalpol propionylated products.

Using electrospray ionization-high resolution mass spectrometry (ESI-HRMS) method to confirm the catalpol propionylated products,and using peak area normalizing method to complete the semi quantitative,the analysis method on the synthesize process of catalpol propionylated products was established. The results showed that the ESI-HRMS method could quickly determine the type of propionylated products; the peak area normalization method could calculate the relative content of each catalpol propionylated products, which could be controlled to synthesize the main or mixed products with the specific structure by controlling the reaction conditions according to the need. The application of ESI-HRMS method in the reaction process of catalpol pro-panolation could provide a new approach for the analysis of the synthesis process of catalpol propanylated products. [ABSTRACT FROM AUTHOR]