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Autoantibodies Targeting Ficolin-2 in Systemic Lupus Erythematosus Patients With Active Nephritis.

Authors :
Colliard, Sophie
Jourde‐Chiche, Noémie
Clavarino, Giovanna
Sarrot‐Reynauld, Françoise
Gout, Evelyne
Deroux, Alban
Fougere, Mélanie
Bardin, Nathalie
Bouillet, Laurence
Cesbron, Jean‐Yves
Thielens, Nicole M.
Dumestre‐Pérard, Chantal
Jourde-Chiche, Noémie
Sarrot-Reynauld, Françoise
Cesbron, Jean-Yves
Dumestre-Pérard, Chantal
Source :
Arthritis Care & Research; Aug2018, Vol. 70 Issue 8, p1263-1268, 6p
Publication Year :
2018

Abstract

<bold>Objective: </bold>Systemic lupus erythematosus (SLE) is a multisystem inflammatory disease characterized by the production of various autoantibodies. The aim of this study was to investigate the presence of anti-ficolin-2 antibodies in SLE patients and to evaluate the association between the levels of these autoantibodies, clinical manifestations, and disease activity.<bold>Methods: </bold>This is a comparative study using a cohort of 165 SLE patients and 48 healthy subjects. SLE patients were further divided into 2 groups (low disease activity [SLE Disease Activity Index (SLEDAI) score ≤4, n = 88] and high disease activity [SLEDAI score >4, n = 77]). Clinical manifestations were defined according to the physician in charge. Active lupus nephritis (LN) was documented by kidney biopsy. Detection of anti-ficolin-2 antibodies was performed by enzyme-linked immunosorbent assay.<bold>Results: </bold>Levels of anti-ficolin-2 autoantibodies were significantly higher in SLE patients as compared to healthy subjects and associated with SLEDAI score. They were found to be positive in 61 of 165 SLE patients (37%). The presence of anti-ficolin-2 antibodies was significantly related only to renal involvement, with a very high prevalence (86%) of anti-ficolin-2 antibodies in SLE patients with active LN. Patients with active proliferative LN had significantly more positive anti-ficolin-2 antibodies than those with nonproliferative LN. The combination of anti-ficolin-2, anti-ficolin-3, and anti-C1q demonstrated a very high specificity (98%) for the diagnosis of active LN.<bold>Conclusion: </bold>Our results support the usefulness of anti-ficolin-2 as a complementary serologic biomarker for the diagnosis of active lupus with renal manifestations. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
2151464X
Volume :
70
Issue :
8
Database :
Complementary Index
Journal :
Arthritis Care & Research
Publication Type :
Academic Journal
Accession number :
130954633
Full Text :
https://doi.org/10.1002/acr.23449