Investigation of FcRL3 Gene Polymorphism (rs7528684) with Susceptibility to Allergic Asthma.

Objective: Fc receptor - like (FCRL) 3 is a transmembrane molecule that has putative roles in B-cell biology, and could be involved in antibody-mediated immune disorders including allergy and asthma, and also in B-cell malignancies. We aimed to investigate the possible association of rs7528684 SNP (-169C/T or FCRL3_3) in FCRL3 gen with predisposition to allergic asthma in Azeri population of Iran. Material and Methods: Frequency of genotypes and alleles of rs7528684 SNP in FCRL3 gene was determined using TaqMan genotyping method in 191 asthmatic patients and 186 healthy controls. Results: The most frequent genotype in patients and control groups were CT (n=81, 42.4%) and TT (n=76, 40.9%) respectively. Statistical analysis showed no significant difference in genotype frequency (p=0.81) and also in frequency of C and T alleles (p=0.52) between two groups. Conclusion: Our results revealed no association between rs7528684 SNP with susceptibility to allergic asthma in Azeri population of Iran. [ABSTRACT FROM AUTHOR]