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Correlation of Neutrophil CD64 with Clinical Profile and Outcome of Sepsis Patients during Intensive Care Unit Stay.
- Source :
- Indian Journal of Critical Care Medicine; Aug2018, Vol. 22 Issue 8, p569-574, 6p, 5 Charts, 3 Graphs
- Publication Year :
- 2018
-
Abstract
- Introduction: Neutrophil CD64 (nCD64) has been found to identify sepsis from nonseptic patients. It is also reported to be a predictor of survival and severity of sepsis. The goal of this study was to correlate serial nCD64 with Intensive Care Unit (ICU) outcome and severity of sepsis. Materials and Methods: A prospective observational study was conducted in 12-bedded critical care unit of a tertiary care center. Adult patients with sepsis were included in this study. Demographics, illness severity scores, clinical parameters, laboratory data, and 28-day outcome were recorded. Serial nCD64 analysis was done (on days 0, 4, and 8) in consecutive patients. Results: Fifty-one consecutive patients were included in the study. Median Acute Physiology and Chronic Health Evaluation II was 16 (12--20) and mean Sequential Organ Failure Assessment was 9 (8--10). Compared to survivors, nonsurvivors had higher nCD64 on day 8 (P = 0.001). nCD64 was higher in the septic shock group compared to sepsis group on days 0 and 8 (P < 0.05). Survivors showed improving trend of nCD64 over time while nonsurvivors did not. This trend was similar in the presence or absence of septic shock. nCD64 count was a good predictor of the septic shock on day 0 (area under the curve [AUC] = 0.747, P = 0.010) and moderate predictor at day 8 (AUC = 0.679, P = 0.028). Conclusion: Monitoring serial nCD64 during ICU stay may be helpful in determining the clinical course of septic patients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09725229
- Volume :
- 22
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Indian Journal of Critical Care Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 131309771
- Full Text :
- https://doi.org/10.4103/ijccm.IJCCM_228_18