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Novel GPC3-binding WS2-Ga3+-PEG-peptide nanosheets for in vivo bimodal imaging-guided photothermal therapy.
- Source :
- Nanomedicine; Jul2018, Vol. 13 Issue 14, pN.PAG-N.PAG, 1p
- Publication Year :
- 2018
-
Abstract
- Aim: The diagnosis and treatment of hepatocarcinoma (HCC) is believed to be improved due to the development of specific targeting probes by molecular imaging methods. GPC3, which is a hepatocellular carcinoma (HCC)-specific tumor marker, anchors at most HCC cells. To target this cell membrane protein, we developed a novel nanoparticle by conjugating WS<subscript>2</subscript>-Ga<superscript>3+</superscript>-PEG and a short peptide with favorable specificity and affinity to the GPC3 protein. Materials & methods: In in vitro assay, several physical properties of the novel probe were evaluated. In in vivo assay, MRI, photoacoustic imaging and photothermal therapy were performed in the subcutaneous HepG2-bearing mice with the novel probe. Results & conclusion: The effect of imaging and photothermal therapy was significant. We revealed that the novel nanosheet WS<subscript>2</subscript>-Ga<superscript>3+</superscript>-PEG-peptide is promising to detect and treat HCC-expressing GPC3. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17435889
- Volume :
- 13
- Issue :
- 14
- Database :
- Complementary Index
- Journal :
- Nanomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 131445873
- Full Text :
- https://doi.org/10.2217/nnm-2017-0367