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Comparison of 3 He and 129 Xe MRI for evaluation of lung microstructure and ventilation at 1.5T.
- Source :
- Journal of Magnetic Resonance Imaging; Sep2018, Vol. 48 Issue 3, p632-642, 11p
- Publication Year :
- 2018
-
Abstract
- <bold>Background: </bold>To support translational lung MRI research with hyperpolarized 129 Xe gas, comprehensive evaluation of derived quantitative lung function measures against established measures from 3 He MRI is required. Few comparative studies have been performed to date, only at 3T, and multisession repeatability of 129 Xe functional metrics have not been reported.<bold>Purpose/hypothesis: </bold>To compare hyperpolarized 129 Xe and 3 He MRI-derived quantitative metrics of lung ventilation and microstructure, and their repeatability, at 1.5T.<bold>Study Type: </bold>Retrospective.<bold>Population: </bold>Fourteen healthy nonsmokers (HN), five exsmokers (ES), five patients with chronic obstructive pulmonary disease (COPD), and 16 patients with nonsmall-cell lung cancer (NSCLC).<bold>Field Strength/sequence: </bold>1.5T. NSCLC, COPD patients and selected HN subjects underwent 3D balanced steady-state free-precession lung ventilation MRI using both 3 He and 129 Xe. Selected HN, all ES, and COPD patients underwent 2D multislice spoiled gradient-echo diffusion-weighted lung MRI using both hyperpolarized gas nuclei.<bold>Assessment: </bold>Ventilated volume percentages (VV%) and mean apparent diffusion coefficients (ADC) were derived from imaging. COPD patients performed the whole MR protocol in four separate scan sessions to assess repeatability. Same-day pulmonary function tests were performed.<bold>Statistical Tests: </bold>Intermetric correlations: Spearman's coefficient. Intergroup/internuclei differences: analysis of variance / Wilcoxon's signed rank. Repeatability: coefficient of variation (CV), intraclass correlation (ICC) coefficient.<bold>Results: </bold>A significant positive correlation between 3 He and 129 Xe VV% was observed (r = 0.860, P < 0.001). VV% was larger for 3 He than 129 Xe (P = 0.001); average bias, 8.79%. A strong correlation between mean 3 He and 129 Xe ADC was obtained (r = 0.922, P < 0.001). MR parameters exhibited good correlations with pulmonary function tests. In COPD patients, mean CV of 3 He and 129 Xe VV% was 4.08% and 13.01%, respectively, with ICC coefficients of 0.541 (P = 0.061) and 0.458 (P = 0.095). Mean 3 He and 129 Xe ADC values were highly repeatable (mean CV: 2.98%, 2.77%, respectively; ICC: 0.995, P < 0.001; 0.936, P < 0.001). DATA CONCLUSION: 129 Xe lung MRI provides near-equivalent information to 3 He for quantitative lung ventilation and microstructural MRI at 1.5T.<bold>Level Of Evidence: </bold>3 Technical Efficacy Stage 2 J. Magn. Reson. Imaging 2018. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10531807
- Volume :
- 48
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Magnetic Resonance Imaging
- Publication Type :
- Academic Journal
- Accession number :
- 131600589
- Full Text :
- https://doi.org/10.1002/jmri.25992