The impacts of pretreatment circulating eosinophils and basophils on prognosis of stage Ⅰ–Ⅲ colorectal cancer.

Abstract: Aim: The effects of circulating eosinophils and basophils on cancer survival are unclear. Here, we aimed to explore the impacts of eosinophils and basophils on prognosis of stage I–III colorectal cancer (CRC) patients. Methods: From February 2003 to March 2013, 569 stage I–III CRC patients were enrolled in this retrospective study. The associations between pretreatment circulating eosinophils, basophils and CRC overall survival (OS), disease‐free survival (DFS) were investigated. Moreover, the prognostic value of combined eosinophils/basophils and neutrophil to lymphocyte ratio (NLR)/platelet to lymphocyte ratio (PLR) was investigated. Results: Kaplan–Meier methods showed the associations of eosinophils < 0.095 × 10⁹/L and shorter OS (P < 0.0001), eosinophils < 0.055 × 10⁹/L and shorter DFS (P < 0.0001), basophils < 0.015 × 10⁹/L and shorter OS (P = 0.001), basophils < 0.015 × 10⁹/L and shorter DFS (P = 0.005). Cox regression model showed that eosinophils < 0.095 × 10⁹/L (hazard ratio [HR], 1.723; 95% confidence intervals [CI] = 1.177–2.523) and basophils < 0.015 × 10⁹/L (HR, 1.714; 95% CI = 1.152–2.548) were independent prognostic factors for OS, and eosinophils < 0.055 × 10⁹/L (HR, 2.309; 95% CI = 1.587–3.361) and basophils < 0.015 × 10⁹/L (HR, 1.397; 95% CI = 1.003–1.945) were independent prognostic factors for DFS, respectively. The combined eosinophil‐PLR (HR, 2.611; 95% CI = 1.328–5.130) and basophil‐PLR (HR, 2.520; 95% CI = 1.240–5.123) were the independent prognostic factors for OS. The combined eosinophil‐NLR (HR, 2.770; 95% CI = 1.528–5.019) and eosinophil‐PLR (HR, 4.788; 95% CI = 2.458–9.329) were the independent prognostic factors for DFS. Conclusion: Pretreatment circulating eosinophils < 0.095 × 10⁹/L/0.055 × 10⁹/L and circulating basophils < 0.015 × 10⁹/L have significant impacts on prognosis of stage I–III CRC patients. [ABSTRACT FROM AUTHOR]