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Effect of Metallothionein-III on Mercury-Induced Chemokine Gene Expression.
- Source :
- Toxics; Sep2018, Vol. 6 Issue 3, p48, 1p
- Publication Year :
- 2018
-
Abstract
- Mercury compounds are known to cause central nervous system disorders; however the detailed molecular mechanisms of their actions remain unclear. Methylmercury increases the expression of several chemokine genes, specifically in the brain, while metallothionein-III (MT-III) has a protective role against various brain diseases. In this study, we investigated the involvement of MT-III in chemokine gene expression changes in response to methylmercury and mercury vapor in the cerebrum and cerebellum of wild-type mice and MT-III null mice. No difference in mercury concentration was observed between the wild-type mice and MT-III null mice in any brain tissue examined. The expression of Ccl3 in the cerebrum and of Cxcl10 in the cerebellum was increased by methylmercury in the MT-III null but not the wild-type mice. The expression of Ccl7 in the cerebellum was increased by mercury vapor in the MT-III null mice but not the wild-type mice. However, the expression of Ccl12 and Cxcl12 was increased in the cerebrum by methylmercury only in the wild-type mice and the expression of Ccl3 in the cerebellum was increased by mercury vapor only in the wild-type mice. These results indicate that MT-III does not affect mercury accumulation in the brain, but that it affects the expression of some chemokine genes in response to mercury compounds. [ABSTRACT FROM AUTHOR]
- Subjects :
- METALLOTHIONEIN
CHEMOKINES
GENE expression
MERCURY vapor
METHYLMERCURY
Subjects
Details
- Language :
- English
- ISSN :
- 23056304
- Volume :
- 6
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Toxics
- Publication Type :
- Academic Journal
- Accession number :
- 131895181
- Full Text :
- https://doi.org/10.3390/toxics6030048