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Icariin and icaritin recover UVB-induced photoaging by stimulating Nrf2/ARE and reducing AP-1 and NF-κB signaling pathways: a comparative study on UVB-irradiated human keratinocytes.
- Source :
- Photochemical & Photobiological Sciences; Oct2018, Vol. 17 Issue 10, p1396-1408, 13p
- Publication Year :
- 2018
-
Abstract
- Icariin (ICA) and icaritin (ICT) exhibit many pharmacological functions including anti-osteoporosis, anti-cardiovascular, and anti-cancer activities; however, there are few comprehensive studies that track the detailed effects on UVB-induced photoaging. The recovery effects of ICA and ICT were investigated in UVB-irradiated human keratinocytes (HaCaTs). The results indicated that ICT and ICA showed strong radical scavenging activity, and the reactive oxygen species (ROS) scavenging activity of ICT was superior. UVB-induced matrix metalloproteinase-1 (MMP-1) expression was blocked by ICA via the inhibition of mitogen-activated protein kinase/activator protein 1 (MAPK/AP-1), which directly reduced extracellular matrix (ECM) degradation. ICT activated nuclear factor erythroid 2 related factor 2 (Nrf2) to improve the anti-oxidative stress capacity and suppress nuclear factor-κB (NF-κB) activation, decreasing vascular endothelial growth factor (VEGF) protein, and inflammatory cytokines induced ECM degrading enzyme secretion. Moreover, ICT was more advantageous to improve transforming growth factor beta 1 (TGF-β1) and procollagen type I expression than ICA, promoting the synthesis of collagen. Therefore, ICA and ICT have potential to treat UVB-induced oxidative stress, inflammation and photoaging, and will be posited as a novel strategy to alleviate photodamage. [ABSTRACT FROM AUTHOR]
- Subjects :
- REACTIVE oxygen species
ANTIOXIDANTS
FIBROBLASTS
GENE expression
APOPTOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 1474905X
- Volume :
- 17
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Photochemical & Photobiological Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 132248108
- Full Text :
- https://doi.org/10.1039/c8pp00174j