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Functionalization of Gadolinium Chelates Silica Nanoparticle through Silane Chemistry for Simultaneous MRI/64Cu PET Imaging.
- Source :
- Contrast Media & Molecular Imaging; 11/1/2018, p1-10, 10p
- Publication Year :
- 2018
-
Abstract
- Multimodal nanoprobes are highly demanded for biomedical imaging applications to enhance the reliability of the diagnostic results. Among different types of nano-objects, ultrasmall silica gadolinium nanoparticle (SiGdNP) appears as a safe, effective, and versatile platform for this purpose. In this study, a new method to functionalize SiGdNP based on silane chemistry has been reported. Two types of chelating silanes (APTES-DOTAGA and APTES-NODAGA) have been synthesized and grafted on SiGdNP by a simple one-step protocol. This functionalization strategy requires no other reactants or catalyzers and does not compromise the ultrasmall size of the particles. NODAGA-functionalized particle has been labeled with <superscript>64</superscript>Cu isotope and injected intravenously to mice bearing TS/A carcinoma tumor for biodistribution study to demonstrate its potential as a bimodal MRI/PET imaging agent. A fully integrated MRI/PET system was used to simultaneously monitor the distribution of the particle. The results showed that the functionalized particle maintained properties of a renal clearable NP which could rapidly escape through kidneys and had low retention in other organs, especially liver, even though its accumulation in the tumor was modest. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15554309
- Database :
- Complementary Index
- Journal :
- Contrast Media & Molecular Imaging
- Publication Type :
- Academic Journal
- Accession number :
- 132770447
- Full Text :
- https://doi.org/10.1155/2018/7938267