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Multiple Nature of the Third Component of Guinea-Pig Complement II. SEPARATION AND DESCRIPTION OF TWO ADDITIONAL FACTORS β AND <em>d</em>; PREPARATION AND CHARACTERIZATION OF FOUR INTERMEDIATE PRODUCTS.
- Source :
- Immunology; Jun65, Vol. 8 Issue 6, p604-617, 14p
- Publication Year :
- 1965
-
Abstract
- Two factors essential for the lysis of EAC'<subscript>142</subscript> cells are described and designated as Β and d. These factors are distinct from the C'<subscript>3</subscript>-subunits a, b and c described earlier; they can be separated by chemical procedures. A simple assay method for both factors is given. Four highly reactive intermediates, EAC'<subscript>142</subscript>,a; EAC'<subscript>142</subscript>,a,b; EAC'<subscript>142</subscript>,a,b,Β and EAC'<subscript>142</subscript>,a,b,Β,c can be prepared and characterized by their lytic reactivity pattern against different systems of incomplete C'<subscript>3</subscript>. Evidence is presented that the subunits of the C'<subscript>3</subscript>-system interact with EAC'<subscript>142</subscript> in a sequential order corresponding to the formula a-b-Β-c-d. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 8
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13278685