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Synthesis, crystal structure and antitumour activity of 3-amino-N-[4-chloro-3-(trifluoromethyl)phenyl]-4-morpholino-1H-indazole-1-carboxamide.
- Source :
- Journal of Chemical Research; Oct2018, Vol. 42 Issue 10, p504-507, 4p
- Publication Year :
- 2018
-
Abstract
- Compound 3-amino-N-[4-chloro-3-(trifluoromethyl)phenyl]-4-morpholino-1H-indazole-1-carboxamide has been synthesised by condensation of 1-chloro-4-isocyanato-2-(trifluoromethyl)benzene with 4-morpholino-1H-indazol-3-amine, which was prepared from 2,6-difluorobenzonitrile by amination with morpholine and then cyclisation with hydrazine hydrate. The crystal structure of the title compound was determined. In addition, the compound possesses a distinct inhibitory capacity against proliferation of the A549 and BGC-823 cancer cell lines. [ABSTRACT FROM AUTHOR]
- Subjects :
- CRYSTAL structure
INDAZOLES
CARBOXAMIDES
X-ray diffraction
ANTINEOPLASTIC agents
Subjects
Details
- Language :
- English
- ISSN :
- 17475198
- Volume :
- 42
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Journal of Chemical Research
- Publication Type :
- Academic Journal
- Accession number :
- 132845938
- Full Text :
- https://doi.org/10.3184/174751918X15380423621264