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Organocatalytic Asymmetric Formal Aza‐[3+3]Cyclo‐additions of 3‐Aminobenzofuran with α,β‐Unsaturated Aldehydes.
- Source :
- Advanced Synthesis & Catalysis; 11/5/2018, Vol. 360 Issue 21, p4168-4177, 10p
- Publication Year :
- 2018
-
Abstract
- An organocatalytic asymmetric formal aza‐[3+3]cycloaddition of readily available N‐Tosyl‐3‐aminobenzofuran with α,β‐unsaturated aldehydes was developed for the first time. This method enables the facile synthesis of biologically active and synthetically challenging polysubstituted fused benzofuran derivatives bearing two stereocenters in high yields with excellent diastereo‐, and enantioselectivity (up to >20 : 1 dr, and >99% ee). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16154150
- Volume :
- 360
- Issue :
- 21
- Database :
- Complementary Index
- Journal :
- Advanced Synthesis & Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- 132896243
- Full Text :
- https://doi.org/10.1002/adsc.201800921