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The Current Status of Drug Discovery and Development as Originated in United States Academia: The Influence of Industrial and Academic Collaboration on Drug Discovery and Development.
- Source :
- CTS: Clinical & Translational Science; Nov2018, Vol. 11 Issue 6, p597-606, 10p
- Publication Year :
- 2018
-
Abstract
- Academic drug discovery is a vital component to current drug discovery and development environments. In this study, we investigated 798 drug discovery projects that took place between 1991 and 2015 at 36 academic institutions in the United States. The observed success rates of academic drug discovery and development were 75% at phase I, 50% at phase II, 59% at phase III, and 88% at the new drug application/biologics license application (NDA/BLA) phase. These results were similar to the corresponding success rates of the pharmaceutical industry. Collaboration between academic institutions and the pharmaceutical industry seemed more important at later stages than earlier ones; all projects that succeeded at phase III or the NDA/BLA stage involved academicāindustrial collaboration. Many academic research projects involved neoplasms and infectious diseases, and were focused on small molecules and biologics. The success rates and possible effects of academicāindustrial collaboration seemed to vary depending on disease domains and drug modalities. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17528054
- Volume :
- 11
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- CTS: Clinical & Translational Science
- Publication Type :
- Academic Journal
- Accession number :
- 132914472
- Full Text :
- https://doi.org/10.1111/cts.12577