Back to Search
Start Over
Intermittent administration of a fasting-mimicking diet intervenes in diabetes progression, restores β cells and reconstructs gut microbiota in mice.
- Source :
- Nutrition & Metabolism; 11/20/2018, Vol. 15 Issue 1, pN.PAG-N.PAG, 1p, 6 Graphs
- Publication Year :
- 2018
-
Abstract
- Fasting and especially intermittent fasting have been shown to be an effective intervention in many diseases, such as obesity and diabetes. The fasting-mimicking diet (FMD) has recently been found to ameliorate metabolic disorders. To investigate the effect of a new type of low-protein low-carbohydrate FMD on diabetes, we tested an FMD in db/db mice, a genetic model of type 2 diabetes. The diet was administered every other week for a total of 8 weeks. The intermittent FMD normalized blood glucose levels in db/db mice, with significant improvements in insulin sensitivity and β cell function. The FMD also reduced hepatic steatosis in the mice. Deterioration of pancreatic islets and the loss of β cells in the diabetic mice were prevented by the FMD. The expression of β cell progenitor marker Ngn3 was increased by the FMD. In addition, the FMD led to the reconstruction of gut microbiota. Intermittent application of the FMD increased the genera of Parabacteroides and Blautia while reducing Prevotellaceae, Alistipes and Ruminococcaceae. The changes in these bacteria were also correlated with the fasting blood glucose levels of the mice. Furthermore, intermittent FMD was able to reduce fasting blood glucose level and increase β cells in STZ-induced type 1 diabetic mouse model. In conclusion, our study provides evidence that the intermittent application of an FMD is able to effectively intervene in the progression of diabetes in mice. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANIMAL experimentation
BACTEROIDES
BLOOD sugar
DIET in disease
DIET therapy
FASTING
FATTY liver
CARBOHYDRATE content of food
GENE expression
GRAM-positive bacteria
INSULIN resistance
ISLANDS of Langerhans
LOW-carbohydrate diet
MICE
TYPE 2 diabetes
DIETARY proteins
GUT microbiome
DISEASE progression
GRAM-negative anaerobic bacteria
Subjects
Details
- Language :
- English
- ISSN :
- 17437075
- Volume :
- 15
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Nutrition & Metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 133089600
- Full Text :
- https://doi.org/10.1186/s12986-018-0318-3