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Asymmetric Phosphine‐Catalyzed [4+1] Annulations of o‐Quinone Methides with MBH Carbonates.
- Source :
- Advanced Synthesis & Catalysis; 12/3/2018, Vol. 360 Issue 23, p4475-4479, 5p
- Publication Year :
- 2018
-
Abstract
- Chiral dihydrobenzofuran units are frequently present in molecules with significant biological and pharmaceutical activities. Herein, we present the first enantioselective formal [4+1] annulation of Morita‐Baylis‐Hillman carbonates with o‐quinone methides (o‐QMs) catalyzed by a newly designed chiral phosphine catalyst. Under the mild and eco‐friendly conditions, a wide range of polysubstituted dihydrobenzofurans were obtained in good yields with excellent enantioselectivities. [ABSTRACT FROM AUTHOR]
- Subjects :
- PHOSPHINE
ANNULATION
QUINONE
CARBONATES
CATALYSTS
Subjects
Details
- Language :
- English
- ISSN :
- 16154150
- Volume :
- 360
- Issue :
- 23
- Database :
- Complementary Index
- Journal :
- Advanced Synthesis & Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- 133370850
- Full Text :
- https://doi.org/10.1002/adsc.201801152