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Grading of Neuroendocrine Carcinomas: Correlation of 68Ga-PET/CT Scan with Tissue Biomarkers.
- Source :
- Disease Markers; 12/2/2018, p1-8, 8p
- Publication Year :
- 2018
-
Abstract
- There is a growing need for more accurate biomarkers to facilitate the diagnosis and prognosis of patients with grade (G) 3 neuroendocrine carcinomas (NECs). In particular, the discrimination between well-differentiated neuroendocrine carcinomas (WD-NECs) and poorly differentiated neuroendocrine carcinomas (PD-NECs) is still an unmet need. We previously showed that <superscript>68</superscript>Gallium-(<superscript>68</superscript>Ga-) PET/CT positivity is a prognostic factor in patients with gastroenteropancreatic (GEP) G3 NECs, correlating with a better outcome in terms of overall survival. Here, we hypothesize that <superscript>68</superscript>Ga-PET/CT could help to discriminate between WD-NECs and PD-NECs, adding complementary information to that obtained from morphologic and biologic factors. A retrospective, single-institution study was performed on 11 patients with histologically confirmed, measurable G3 large- or small-cell GEP-NECs according to the 2017 WHO classification. The staging procedures included a <superscript>68</superscript>Ga-PET/CT scan. Results of <superscript>68</superscript>Ga-PET/CT were correlated in univariate analysis with loss of tissue immunohistochemical expression of DAXX/ATRX or RB1 frequently associated with WD-NECs or PD-NECs, respectively. None of the patients with positive <superscript>68</superscript>Ga-PET/CT showed loss of RB1 expression, whereas among those (n=6) with negative <superscript>68</superscript>Ga-PET/CT, 4 showed loss of expression. A trend towards a correlation between loss of RB1 expression and negative <superscript>68</superscript>Ga-PET/CT was observed. Our preliminary data support the hypothesis that PD-NECs carrying RB1 mutation and loss of its expression may be associated with negative <superscript>68</superscript>Ga-PET/CT. If confirmed in a larger clinical trial, <superscript>68</superscript>Ga-PET/CT would help in the stratification of G3 NECs. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02780240
- Database :
- Complementary Index
- Journal :
- Disease Markers
- Publication Type :
- Academic Journal
- Accession number :
- 133381534
- Full Text :
- https://doi.org/10.1155/2018/6878409