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Theranostic radioiodine-labelled melanin nanoparticles inspired by clinical brachytherapy seeds.
- Source :
- Journal of Materials Chemistry B; 12/28/2018, Vol. 6 Issue 48, p8163-8169, 7p
- Publication Year :
- 2018
-
Abstract
- Radioiodine is widely used in nuclear medicine, mainly serving as a tracer and therapeutic agent, and benefits from its various radioactive isotopes of iodine including I-123, I-124, I-125, I-131 and so on. Melanin is a natural material widely dispersed in the human skin, hair and eyes. The excellent biocompatibility and multifunctional abilities of melanin make it a perfect carrier for biomedical applications. Here, we fabricated theranostic radioiodine-labelled melanin nanoparticles (MNPs) through a novel Ag–I two-step method. The Ag–I labelling method for MNP radioiodine-labelling has advantages including a faster labelling time, higher labelling yield, and higher stability than the chloramine-T oxidation method reported previously. The obtained MNP–Ag–<superscript>131</superscript>I can be used for both single-photon emission computed tomography and Cherenkov radiation imaging. The β-rays of <superscript>131</superscript>I also make it a good candidate as a cancer cell killer. The theranostic properties of this nanoparticle were also proved in a xenograft tumor model in vivo. In summary, this study provides a new concept for radioiodine labelling nanoparticles, which can be further investigated in various imaging and radiotherapy applications with different radioactive isotopes of iodine. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 2050750X
- Volume :
- 6
- Issue :
- 48
- Database :
- Complementary Index
- Journal :
- Journal of Materials Chemistry B
- Publication Type :
- Academic Journal
- Accession number :
- 133526854
- Full Text :
- https://doi.org/10.1039/c8tb02817f