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Activation of a murine T-cell hybridoma by cationized bacteria.
- Source :
- Immunology; Aug89, Vol. 67 Issue 4, p478-483, 6p
- Publication Year :
- 1989
-
Abstract
- Cationic particles interact by electrostatic forces with membrane components of diverse cell types, including lymphocytes. Contact with cationized streptococci was shown to induce a murine T-cell hybridoma to transcribe lymphokine mRNA as well as secrete interleukin-2. This activation was accompanied by a rise in intracellular calcium. Cationized streptococci-induced activation of this T-cell hybridoma could be specifically inhibited by either chelating extracellular calcium or by treating with CD4 monoclonal antibody. These data indicate that the in vitro behaviour of T cells can be modulated by charged microbial particles; such interactions may have relevance for chronic inflammation associated with some bacterial infections. [ABSTRACT FROM AUTHOR]
- Subjects :
- LYMPHOCYTES
LEUCOCYTES
B cells
IMMUNOGLOBULINS
GLOBULINS
PLASMA cells
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 67
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13358044