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Microfluidic bioanalytical flow cells for biofilm studies: a review.

Authors :
Pousti, Mohammad
Zarabadi, Mir Pouyan
Abbaszadeh Amirdehi, Mehran
Paquet-Mercier, François
Greener, Jesse
Source :
Analyst; 1/7/2019, Vol. 144 Issue 1, p68-86, 19p
Publication Year :
2019

Abstract

Bacterial biofilms are among the oldest and most prevalent multicellular life forms on Earth and are increasingly relevant in research areas related to industrial fouling, medicine and biotechnology. The main hurdles to obtaining definitive experimental results include time-varying biofilm properties, structural and chemical heterogeneity, and especially their strong sensitivity to environmental cues. Therefore, in addition to judicious choice of measurement tools, a well-designed biofilm study requires strict control over experimental conditions, more so than most chemical studies. Due to excellent control over a host of physiochemical parameters, microfluidic flow cells have become indispensable in microbiological studies. Not surprisingly, the number of lab-on-chip studies focusing on biofilms and other microbiological systems with expanded analytical capabilities has expanded rapidly in the past decade. In this paper, we comprehensively review the current state of microfluidic bioanalytical research applied to bacterial biofilms and offer a perspective on new approaches that are expected to drive continued advances in this field. [ABSTRACT FROM AUTHOR]

Subjects

Subjects :
BIOFILMS
FOULING
HETEROGENEITY

Details

Language :
English
ISSN :
00032654
Volume :
144
Issue :
1
Database :
Complementary Index
Journal :
Analyst
Publication Type :
Academic Journal
Accession number :
133609034
Full Text :
https://doi.org/10.1039/c8an01526k