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Effects of Hormones on Development and Function of Lymphoid II. DELAYED DEVELOPMENT OF IMMUNOLOGICAL CAPACITY IN PITUITARY DWARF MICE.
- Source :
- Immunology; Sep71, Vol. 21 Issue 3, p455-461, 7p
- Publication Year :
- 1971
-
Abstract
- The present report describes the morphology of lymphoid tissues and the humoral antibody response during primary and secondary immune responses to sheep erythrocytes (SRBC) in Snell-Bagg hereditary pituitary dwarf mice. It has been found that while 19S primary response was depressed to a great extent, 7S secondary response reached practically normal levels. Histological studies of the peripheral lymphoid tissues have shown patterns of cellular depletion in nonthymus-dependent areas in dwarfs killed during primary response, while these areas appeared markedly cellular after a second antigenic stimulation. It is suggested that the cell systems involved in antibody production during primary and secondary responses to SRBC may be separate and different. As a result, the endocrine imbalance of the dwarf mice affects only the primary response to SRBC. [ABSTRACT FROM AUTHOR]
- Subjects :
- IMMUNE system
HORMONES
LYMPHOID tissue
IMMUNOGLOBULINS
ERYTHROCYTES
IMMUNE response
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 21
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13362982