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Immunological Disease Induced by Injecting F1 Lymphoid Cells into Certain Parental Strains.
- Source :
- Immunology; Dec74, Vol. 27 Issue 6, p989-1007, 19p
- Publication Year :
- 1974
-
Abstract
- Injection of neonatal Balb/c or C57B1/6 mice with (C57B1/6x Balb/c)F1 lymphoid cells leads to transient chimerism and runting, and to splenomegaly, deficient T-cell function and a gradual replacement of lymphoid organs with abnormal reticular cells. Activated MuLV can be isolated from such mice. It is proposed that either graft-versus-host or host-versus-graft allogeneic reactivity activates endogenous MuLV virus, which then causes functional and morphological abnormalities in the lymphoid organs. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 27
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13364319