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Naturally Occurring Double-stranded RNA and Immune Responses I. EFFECTS ON PLAQUE-FORMING CELLS AND ANTIBODY FORMATION.
- Source :
- Immunology; Mar75, Vol. 28 Issue 3, p451-468, 18p
- Publication Year :
- 1975
-
Abstract
- A highly purified preparation of double-stranded RNA, obtained from virus-like particles in Penicllium cultures, was found to affect humoral immune responses in mice differentially depending on its time of administration in relation to antigen. Double-stranded RNA administered with antigen, or a few hours after antigen, produced a variable degree of enhancement of plaque-forming cell numbers or agglutinating antibody levels depending on the antigen involved. Administration of double-stranded RNA 24 hours before antigen invariably produced a suppressed response. In mice which were either specifically byporesponsive (tolerant) or non-specifically hyporesponsive (due to age or immunosuppressive drags) double-stranded RNA administered with antigen resulted in a nearly normal immune response. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 28
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13371923