T Cell-dependent Mediator in the Immune Response.

Evidence is presented which suggests that T cell-dependent non-specific factor (NSF) cannot be the sole mediator of 'co-operation' for all types of thymus-dependent antibody response. NSF can replace the requirement for T cells in responses to hapten conjugated to particulate carriers, but cannot do so in responses to hapten conjugates of soluble thymus-dependent carriers. [ABSTRACT FROM AUTHOR]