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Autoreactivity developing spontaneously in cultured mouse spleen cells I. EVIDENCE THAT CYTOTOXICITY IS DIRECTED AGAINST EMBRYO-ASSOCIATED ANTIGEN.
- Source :
- Immunology; Oct76, Vol. 31 Issue 4, p607-614, 8p
- Publication Year :
- 1976
-
Abstract
- We have investigated the ability of male-mouse spleen cells before and after culture in the absence of deliberate antigenic stimulation to show specific cytotoxicity to syngeneic embryo-fibroblast cells. The data suggest that cytotoxicity which develops spontaneously in such spleen cell cultures is directed primarily against embryo-associated antigens. Syngeneic Con-A-stimulated spleen cells, which, unlike fresh normal spleen cells, are also lysed by rabbit anti-mouse embryo antisera, are also a suitable target to demonstrate spontaneously developing cytotoxicity. [ABSTRACT FROM AUTHOR]
- Subjects :
- CELL-mediated cytotoxicity
ANTIGENS
SPLEEN
CELLS
LABORATORY mice
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 31
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13373295