ICAM-1/LFA-1 interactions in T-lymphocyte activation and adhesion to cells of the blood-retina barrier in the rat.

Examines the effects of monoclonal antibodies to rat adhesion/accessory molecules on the binding of normal and concanavalin A-activated rat spleen lymphocytes to cultured unstimulated and interferon-gamma-stimulated endothelium and pigment epithelium. Data demonstrating that the system is important in lymphocyte trafficking into the eye only after lymphocyte activation.