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Involvement of γδ T cells in immunity to trypanosomiasis.
- Source :
- Immunology; Sep94, Vol. 83 Issue 1, p86-92, 7p
- Publication Year :
- 1994
-
Abstract
- In this study the involvement of peripheral γδ T cells, prepared by flow cytometry, in the immune response of cattle to primary infection with Trypanosoma congolense was assessed. Negligible in vitro proliferative responses were observed in γδ T cells isolated from trypanosusceptible Boran (Bos indicus) cattle at all stages examined post-infection when stimulated in vitro with parasite antigens. In contrast, both CD8<superscript>+</superscript> T cells and γδ T cells from trypanotolerant N'Dama (Bos taurus) cattle proliferated markedly when stimulated in vitro with a complex of invariant trypanosome antigens with MW between 100 000 and 140 000 (100 000 MW complex). Neither species of cattle exhibited significant T-cell recognition of trypanosome variable surface glycoprotein (VSG). To study further the functional and phenotypic characteristics of the γδ T-cell response, four T-cell lines were established from infected N'Dama cattle. These cell lines were comprised of up to 96% γδ (WC1<superscript>+</superscript>) T cells, the remainder being CD8<superscript>+</superscript> T cells. Two of these γδ T-cell lines exhibited 100 000 MW complex antigen specificity which was not major histocompatibility complex (MHC) restricted in one line. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cells
LYMPHOCYTES
TRYPANOSOMIASIS
PROTOZOAN diseases
IMMUNOGLOBULINS
IMMUNITY
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 83
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13373378