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Regulation of the immune response in autoimmune NZB/NZW F1 mice II. AGE DEPENDENT RELEASE OF SUPPRESSIVE FACTORS FROM SPLEEN CELLS.
- Source :
- Immunology; Jun78, Vol. 34 Issue 6, p1017-1025, 9p
- Publication Year :
- 1978
-
Abstract
- Suppressor cells in the spleens of overtly autoimmune NZB &xtimes; NZW (B/W) mice, but not age matched normal strain mice, were shown to release a small, <20,000 Dalton factor which inhibited early events in the anti-SRBC PFC response and the mitogenic response. This splenic inhibitory factor (SIF) was (i) stable on heating (56°, 30 min) and freezing (-70°); (ii) non-specific for antigen; (iii) absorbed and/or inactivated by target cells in young B/W spleen cell cultures and (iv) released gradually into the culture medium by metabolically active cells. SIF also blocked the T-cell replacing effect of allogeneic factors (TRF) in the anti-SRBC response. These observations suggest that SIF may lead to the immunodepressed state in overtly autoimmune B/W mice by preventing the activation or differentiation of lymphocytes responding to exogenous antigen. [ABSTRACT FROM AUTHOR]
- Subjects :
- IMMUNE response
SPLEEN
MICE
SUPPRESSOR cells
T cells
AUTOIMMUNITY
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 34
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13393605