The Italian Mastocytosis Registry: 6-year experience from a hospital-based registry.

<bold>Aim: </bold>We collected 'real-life' data on the management of patients with mastocytosis in the Italian Mastocytosis Registry.<bold>Methods: </bold>Six hundred patients diagnosed with mastocytosis between 1974 and 2014 were included from 19 centers.<bold>Results: </bold>Among adults (n = 401); 156 (38.9%) patients were diagnosed with systemic mastocytosis. In 212 adults, no bone marrow studies were performed resulting in a provisional diagnosis of mastocytosis of the skin. This diagnosis was most frequently established in nonhematologic centers. In total, 182/184 pediatric patients had cutaneous mastocytosis. We confirmed that in the most patients with systemic mastocytosis, serum tryptase levels were >20 ng/ml and KIT D816V was detectable.<bold>Conclusion: </bold>The Italian Mastocytosis Registry revealed some center-specific approaches for diagnosis and therapy. Epidemiological evidence on this condition is provided. [ABSTRACT FROM AUTHOR]