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Helper activity of T lymphocytes which have been stimulated by keyhole limpet haemocyanin <em>in vitro</em>.
- Source :
- Immunology; May81, Vol. 43 Issue 1, p111-116, 6p
- Publication Year :
- 1981
-
Abstract
- Details are given of a system for keyhole limpet haemocyanin (KLH)-induced DNA synthesis by murine T lymphocytes in vitro. Lymph node T cells from mice primed with KLH and Bordetella pertussis were stimulated with KLH under the defined conditions, and it was found that such cultured cells exhibited substantial non-specific helper activity. In contrast similarly primed T cells which had not been cultured showed only antigen-specific help. it is concluded that proper account should be taken of nonspecific effects when studying the activity of antigen-specific helper cells in in vitro. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cells
HEMOCYANIN
DNA synthesis
LYMPH nodes
BORDETELLA pertussis
ANTIGENS
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 43
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13395929