Immature chicken B cells with immunocompetence restricted to IgM type do not elicit the formation of germinal centres.

Chickens depleted of both T and B cells were restored with T cells and with immature B cells capable of producing IgM only, and immunized with sheep red blood cells. These chickens developed strikingly few germinal centres, in marked contrast to controls which received normal adult B cells. [ABSTRACT FROM AUTHOR]