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A Proposition on the Distribution of Antibody Affinities, with Implications for the Mechanism of B-cell Activation.
- Source :
- Immunology; Dec75, Vol. 29 Issue 6, p989-999, 11p
- Publication Year :
- 1975
-
Abstract
- For most antisera a linear relationship can be shown between log antigen concentration and the log concentration of antibody required to bind half the available antigen. This paper shows that the slope of this line, s, is related to the distribution of individual antibody clonotypes of different affinity. It is argued that the general form of the distribution approximates to exponential (rather than for example Gaussian) and that this indicates a requirement for some force to be exerted through the antigen-receptor bond in order to activate a B cell. An alternative parameter, A, which gives more weight to high affinity clonotypes, is offered in place of K<subscript>0</subscript> as a measure of the avidity and biological effectiveness of an antiserum. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANTIGENS
IMMUNOGLOBULINS
B cells
SERUM
LYMPHOCYTES
PLASMA cells
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 29
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13405564