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Bewertung einer leitlinienbasierten Konturierung von Herzunterstrukturen bei linksseitigen Brustkrebspatientinnen im Rahmen einer adjuvanten Strahlentherapie : Qualitätsbeurteilung innerhalb einer Phase-III-Studie zum Test einer kardioprotektiven Behandlungsstrategie (SAFE-2014).
- Source :
- Strahlentherapie und Onkologie; Jan2019, Vol. 195 Issue 1, p43-51, 9p
- Publication Year :
- 2019
-
Abstract
- <bold>Background and Purpose: </bold>In our institute, breast cancer patients undergoing adjuvant treatment are included in a protocol aimed to reduce cardiovascular morbidity (SAFE-2014, NCT2236806), assessing preclinical heart damage with heart speckle-tracking ultrasound. To develop a dose constraint related to subclinical heart damage, a reliable delineation of heart substructures based on a pre-existing guideline was made.<bold>Patients and Methods: </bold>Heart substructures of 16 left-sided breast cancer patients included in the SAFE protocol were delineated by five operators. For each substructure, a multi-contour delineation based on a majority vote algorithm (MCD) was created. A consensus-based delineation (CBD) was developed by an independent team of two blinded operators. Dice similarity coefficients (DSC) between volumes delineated by different operators and the MCD were collected and reported, as well as DSC between CBD and MCD.<bold>Results: </bold>Mean DSCs between heart chambers delineated by each operator and the corresponding MCDs ranged between 0.78 and 0.96. Mean DSC between substructures delineated by all single operators and the corresponding MCD ranged between 0.84 and 0.94. Mean DSC between CBD and the corresponding MCD ranged from 0.89 to 0.97.<bold>Conclusion: </bold>Results showed low inter-observer variability of heart substructure delineation. This constitutes an external validation of the contouring atlas used, allowing a reliable dosimetric assessment of these volumes within the SAFE-2014 trial. [ABSTRACT FROM AUTHOR]
- Subjects :
- ALGORITHMS
CARDIOTONIC agents
CARDIOVASCULAR agents
COMBINATION drug therapy
CLINICAL trials
COMBINED modality therapy
COMPARATIVE studies
DOPPLER echocardiography
HEART
RESEARCH methodology
MEDICAL cooperation
MEDICAL protocols
QUALITY assurance
RADIATION measurements
RADIATION injuries
RADIOTHERAPY
RESEARCH
RESEARCH evaluation
STATISTICAL sampling
RAMIPRIL
EVALUATION research
RANDOMIZED controlled trials
RESEARCH bias
PREVENTION
Subjects
Details
- Language :
- English
- ISSN :
- 01797158
- Volume :
- 195
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Strahlentherapie und Onkologie
- Publication Type :
- Academic Journal
- Accession number :
- 134098098
- Full Text :
- https://doi.org/10.1007/s00066-018-1388-x