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Bewertung einer leitlinienbasierten Konturierung von Herzunterstrukturen bei linksseitigen Brustkrebspatientinnen im Rahmen einer adjuvanten Strahlentherapie : Qualitätsbeurteilung innerhalb einer Phase-III-Studie zum Test einer kardioprotektiven Behandlungsstrategie (SAFE-2014).

Authors :
Francolini, Giulio
Desideri, Isacco
Meattini, Icro
Becherini, Carlotta
Terziani, Francesca
Olmetto, Emanuela
Delli Paoli, Camilla
Pezzulla, Donato
Loi, Mauro
Bonomo, Pierluigi
Greto, Daniela
Calusi, Silvia
Casati, Marta
Pallotta, Stefania
Livi, Lorenzo
Source :
Strahlentherapie und Onkologie; Jan2019, Vol. 195 Issue 1, p43-51, 9p
Publication Year :
2019

Abstract

<bold>Background and Purpose: </bold>In our institute, breast cancer patients undergoing adjuvant treatment are included in a protocol aimed to reduce cardiovascular morbidity (SAFE-2014, NCT2236806), assessing preclinical heart damage with heart speckle-tracking ultrasound. To develop a dose constraint related to subclinical heart damage, a reliable delineation of heart substructures based on a pre-existing guideline was made.<bold>Patients and Methods: </bold>Heart substructures of 16 left-sided breast cancer patients included in the SAFE protocol were delineated by five operators. For each substructure, a multi-contour delineation based on a majority vote algorithm (MCD) was created. A consensus-based delineation (CBD) was developed by an independent team of two blinded operators. Dice similarity coefficients (DSC) between volumes delineated by different operators and the MCD were collected and reported, as well as DSC between CBD and MCD.<bold>Results: </bold>Mean DSCs between heart chambers delineated by each operator and the corresponding MCDs ranged between 0.78 and 0.96. Mean DSC between substructures delineated by all single operators and the corresponding MCD ranged between 0.84 and 0.94. Mean DSC between CBD and the corresponding MCD ranged from 0.89 to 0.97.<bold>Conclusion: </bold>Results showed low inter-observer variability of heart substructure delineation. This constitutes an external validation of the contouring atlas used, allowing a reliable dosimetric assessment of these volumes within the SAFE-2014 trial. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01797158
Volume :
195
Issue :
1
Database :
Complementary Index
Journal :
Strahlentherapie und Onkologie
Publication Type :
Academic Journal
Accession number :
134098098
Full Text :
https://doi.org/10.1007/s00066-018-1388-x