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Concanavalin-A displays leishmanicidal activity by inducing ROS production in human peripheral blood mononuclear cells.
- Source :
- Immunopharmacology & Immunotoxicology; Oct2018, Vol. 40 Issue 5, p387-392, 6p
- Publication Year :
- 2018
-
Abstract
- The context of the article: Leishmania amazonensis has a wide geographical distribution throughout South American countries and can cause self-healing to severe cases as mucocutaneous or visceral forms. Leishmaniasis presents a balance of inflammatory and anti-inflammatory cytokines which is responsible for promoting the activation of phagocytes, essential to control the infection and lead to tissue repair/resolution of the disease, respectively. Results and discussion: Our model revealed that the treatment with Con-A was capable to stimulate human PBMC cells by increasing the phagocytic capacity and promoting parasite elimination. The pretreatment with Con-A promoted inflammatory (IFN-γ, TNF-α, IL-2 and IL-6) and anti-inflammatory (IL-4 and IL-10) cytokines production, increased the reactive oxygen species (ROS) sinthesys as well as the expression and presence of iNOS enzyme, but not nitric oxide production. Conclusion: Based on the data obtained, it was possible to infer that Con-A induces the ROS production, responsible for eliminating parasites in addition to regulatory cytokines synthesis which are important for disease resolution. [ABSTRACT FROM AUTHOR]
- Subjects :
- IMMUNE response
CYTOKINES
NITRIC oxide
NITROGEN compounds
CELLULAR immunity
Subjects
Details
- Language :
- English
- ISSN :
- 08923973
- Volume :
- 40
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Immunopharmacology & Immunotoxicology
- Publication Type :
- Academic Journal
- Accession number :
- 134137468
- Full Text :
- https://doi.org/10.1080/08923973.2018.1510960