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Short-Term Steroid Regimen for Adult Steroid-Sensitive Minimal Change Disease.
- Source :
- American Journal of Nephrology; Jan2019, Vol. 49 Issue 1, p54-63, 10p, 2 Diagrams, 4 Charts, 2 Graphs
- Publication Year :
- 2019
-
Abstract
- <bold>Background: </bold>In pediatric patients with steroid-sensitive nephrotic syndrome, recent trials have revealed that a 2-month, short-term steroid regimen is not inferior to an extended steroid course. However, the optimal duration of initial steroid therapy for adult steroid-sensitive minimal change disease (MCD) remains unclear.<bold>Objectives: </bold>The aim of present study was to evaluate the effectiveness of a 2-month, short-term steroid regimen in the treatment of adult steroid-sensitive MCD patients.<bold>Method: </bold>This was a prospective observational study. Adult patients with steroid-sensitive MCD (n = 35) who were initiated on a short-term steroid regimen between January 2015 and June 2016 were included. The details of the regimen are as follows: (1) prednisolone was administered at an initial dose of 0.8-1.0 mg/kg/day and continued for 4-6 weeks and (2) dosage was reduced to 0.5-0.6 mg/kg/alternate day and continued for 4 weeks. Control patients (n = 140), who were treated using conventional steroid administration, were selected from our previous adult MCD cohort. All patients fulfilled the following criteria: biopsy-proven MCD, age ≥20 years, first episode of nephrotic syndrome, and attainment of complete remission within 4 weeks. The following parameters of patients who received short-term treatment regimen and control patients were compared: any relapse and frequent relapse, adverse events caused by steroid treatment and cumulative steroid dose.<bold>Results: </bold>Throughout the observation period (median: 17.3 months), 24 (68.6%) patients in the short-term group developed at least one relapse. The short-term regimen showed earlier occurrence of any relapse than the conventional regimen (adjusted hazard ratio [aHR] 2.45; 95% CI 1.51-3.97; p < 0.001), but there was no difference in frequent relapse (aHR 1.31; 95% CI 0.43-3.99; p = 0.63). None of the patients showed any symptoms of adrenal insufficiency after discontinuation of corticosteroids. The cumulative steroid dose during the observational period was significantly lower in the short-term group than in the conventional group.<bold>Conclusions: </bold>The short-term steroid regimen may represent an effective treatment option that ensures lower steroid exposure when treating adult steroid-sensitive MCD patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- NEPHROTIC syndrome in children
STEROID drugs
PREDNISOLONE
IMMUNOSUPPRESSION
COHORT analysis
DISEASE relapse prevention
KIDNEY disease diagnosis
GLUCOCORTICOIDS
RESEARCH
BIOPSY
TIME
RESEARCH methodology
KIDNEY tubules
EVALUATION research
MEDICAL cooperation
KIDNEY diseases
TREATMENT effectiveness
DRUG administration
COMPARATIVE studies
DOSE-effect relationship in pharmacology
MENTAL health surveys
PREDNISONE
DISEASE remission
LONGITUDINAL method
Subjects
Details
- Language :
- English
- ISSN :
- 02508095
- Volume :
- 49
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- American Journal of Nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 134186884
- Full Text :
- https://doi.org/10.1159/000495352