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Syntheses, crystal structures, DFT, molecular docking and inhibition studies of jack been urease by nickel (II) and copper (II) Schiff base complexes.
- Source :
- Inorganic & Nano-Metal Chemistry; 2018, Vol. 48 Issue 4/5, p211-224, 14p
- Publication Year :
- 2018
-
Abstract
- Ni (II) and Cu (II) complexes [Ni(L)<subscript>2</subscript>] (1) and [Cu(L)<subscript>2</subscript>].H<subscript>2</subscript>O (2) was synthesized using a Schiff base (HL) ligand which was formed by 5-bromosalicylaldehyde with 2-methoxybenzeneamine. The crystal structure of the ligand and its complexes were determined through crystal X-ray diffraction. The most plausible geometry for the 1:2 complexes appeared to be distorted octahedral. The TG-DTA analysis of complex (1) and (2) exhibits an exothermic peaks at around 367-393 °C. Their inhibition studies was performed on urease. Complex (1) and (2) can inhibit urease activity, with IC<subscript>50</subscript> values of 2.10 ± 0.06 and 2.10 ± 0.10 µmol L<superscript>−1</superscript>, respectively. Their DFT study were also discussed. [ABSTRACT FROM AUTHOR]
- Subjects :
- CRYSTAL structure
MOLECULAR docking
SCHIFF bases
UREASE
COPPER compounds
Subjects
Details
- Language :
- English
- ISSN :
- 24701556
- Volume :
- 48
- Issue :
- 4/5
- Database :
- Complementary Index
- Journal :
- Inorganic & Nano-Metal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 134392841
- Full Text :
- https://doi.org/10.1080/24701556.2018.1503679