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Malt1 inactivation attenuates experimental colitis through the regulation of Th17 and Th1/17 cells.
- Source :
- Inflammation Research; Mar2019, Vol. 68 Issue 3, p223-230, 8p
- Publication Year :
- 2019
-
Abstract
- Objective and design: Protease activity of MALT lymphoma-translocation protein 1 (Malt1) plays an important role in the development of colitis, but the detailed mechanism has not been fully elucidated.Method: Effects of Malt1 protease on the activation of T cells and the development of experimental colitis was investigated using Malt1 protease-deficient (PD) mouse.Results: IL-2 production from CD4<superscript>+</superscript> T cells of Malt1 PD mice was decreased compared with that of wild-type (WT) mice. Intraperitoneal injection of anti-CD3 antibody into Malt1 PD mouse induced less productions of IL-17 in the plasma, as well as the colonic gene expression of IL-17A, compared with WT mice, whereas IFN-γ production was not impaired. In naïve T-cell transfer colitis model, Malt1 PD T cells induced less disease severity than WT T cells. Then, reduction in the populations of Th17 and Th1/17 cells was observed in the mesenteric lymph nodes of the recipient mice transferred with Malt1 PD T cells, whereas those of Th1 cells were not impaired. IL-17A expression in the colon was also decreased in the mouse receiving Malt1 PD T cells.Conclusions: Inactivation of Malt1 protease activity abrogates Th17 and Th1/17 cell activation, resulting in the amelioration of experimental colitis. [ABSTRACT FROM AUTHOR]
- Subjects :
- INTRAPERITONEAL injections
COLITIS
T cells
TH1 cells
CELLS
Subjects
Details
- Language :
- English
- ISSN :
- 10233830
- Volume :
- 68
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Inflammation Research
- Publication Type :
- Academic Journal
- Accession number :
- 134585148
- Full Text :
- https://doi.org/10.1007/s00011-018-1207-y