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Benzyne-mediated trichloromethylation of chiral oxazolines.
- Source :
- Chemical Communications; 2/18/2019, Vol. 55 Issue 14, p2070-2073, 4p
- Publication Year :
- 2019
-
Abstract
- A three-component reaction between benzyne, oxazolines and chloroform was developed for the synthesis of trichloromethylated chiral oxazolidines. Benzyne not only serves as an electrophile towards oxazolines but also acts as a base for the deprotonation of chloroform. The dual functions of benzyne enable the trichloromethylation of chiral oxazolines and thus construct chiral N,O-quaternary stereocenters. [ABSTRACT FROM AUTHOR]
- Subjects :
- METHYLATION
ELECTROPHILES
OXAZOLINE
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 55
- Issue :
- 14
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 134648361
- Full Text :
- https://doi.org/10.1039/c9cc00557a