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Artificial K+ Channels Formed by Pillararene‐Cyclodextrin Hybrid Molecules: Tuning Cation Selectivity and Generating Membrane Potential.
- Source :
- Angewandte Chemie International Edition; 2/25/2019, Vol. 58 Issue 9, p2779-2784, 6p
- Publication Year :
- 2019
-
Abstract
- A class of artificial K+ channels formed by pillararene‐cyclodextrin hybrid molecules have been designed and synthesized. These channels efficiently inserted into lipid bilayers and displayed high selectivity for K+ over Na+ in fluorescence and electrophysiological experiments. The cation transport selectivity of the artificial channels is tunable by varying the length of the linkers between pillararene and cyclodexrin. The shortest channel showed specific transmembrane transport preference for K+ over all alkali metal ions (selective sequence: K+ > Cs+ > Rb+ > Na+ > Li+), and is rarely observed for artificial K+ channels. The high selectivity of this artificial channel for K+ over Na+ ensures specific transmembrane translocation of K+, and generated stable membrane potential across lipid bilayers. Old pals: A pillararene‐cyclodextrin hybrid molecule with artificial K+ channel function is presented. The cation transport selectivity of the artificial channel is tunable. The high selectivity of this artificial channel for K+ over Na+ ensures specific transmembrane translocation of K+, and generated a stable membrane potential across lipid bilayers. [ABSTRACT FROM AUTHOR]
- Subjects :
- POTASSIUM channels
CYCLODEXTRINS
ELECTROPHYSIOLOGY
MEMBRANE proteins
METAL ions
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 58
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 134777195
- Full Text :
- https://doi.org/10.1002/anie.201813797