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Black Rice (Oryza sativa L.) Fermented with Lactobacillus casei Attenuates Osteoclastogenesis and Ovariectomy-Induced Osteoporosis.
- Source :
- BioMed Research International; 2/19/2019, p1-16, 16p
- Publication Year :
- 2019
-
Abstract
- The aim of the present study was to investigate the antiosteoclastogenic effects of black rice (Oryza sativa L.) fermented with Lactobacillus casei (LAB) in RANKL-induced RAW macrophage cells and its antiosteoporosis activity against ovariectomy-induced osteoporosis in rats. LAB extract (LABE) treatment attenuated receptor activator of nuclear factor-kappa B (NF-κB) ligand-induced osteoclastic differentiation in RAW cells by inhibiting intercellular reactive oxygen species generation and downregulating the activation of mitogen-activated protein kinases and NF-κB, leading to the downregulation of c-Fos and expression of nuclear factor of activated T cells c1. This consequently suppressed the expression of osteoclast-specific genes including those for cathepsin K, tartrate-resistant acid phosphatase, calcitonin receptor, and integrin β3. Oral administration of LABE protected against ovariectomy-induced bone loss by significantly inhibiting bone architecture alterations and improving serum bone turnover markers in ovariectomized rats. The findings suggest that the antiosteoporotic activity of LABE may be derived from its antiosteoclastic and anti-bone-resorptive activities. LABE has potential as a promising functional material or substrate to prepare protective agents for osteoporosis and osteoclast-mediated bone diseases. [ABSTRACT FROM AUTHOR]
- Subjects :
- ACID phosphatase
REACTIVE oxygen species
ANIMAL experimentation
ANTIGENS
BIOMARKERS
BONE resorption
BONE growth
CELL differentiation
CELL receptors
FERMENTATION
GENE expression
LACTOBACILLUS
MACROPHAGES
ONCOGENES
ORAL drug administration
OSTEOPOROSIS
OVARIECTOMY
PROTEIN kinases
PROTEOLYTIC enzymes
RATS
RICE
T cells
TUMOR necrosis factors
DNA-binding proteins
Subjects
Details
- Language :
- English
- ISSN :
- 23146133
- Database :
- Complementary Index
- Journal :
- BioMed Research International
- Publication Type :
- Academic Journal
- Accession number :
- 134793320
- Full Text :
- https://doi.org/10.1155/2019/5073085