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Protective effect of 6-O-methyl-scutellarein on repeated cerebral ischemia/reperfusion in rats.
- Source :
- Journal of Asian Natural Products Research; Dec2018, Vol. 20 Issue 12, p1167-1181, 15p
- Publication Year :
- 2018
-
Abstract
- Scutellarin (1) possesses protective effects against neuronal injury, while 6-O-methyl-scutellarein (3), as the main metabolite of scutellarin in vivo, has not been reported about its protective effects previously. The present study mainly investigated whether the neural injury caused by ischemia/reperfusion would be influenced by different doses of 6-O-methyl-scutellarein (3). The results of behavioral, neurological, and histological examinations indicated that 6-O-methyl-scutellarein (3) could improve neuronal injury, and exhibit significant difference among the various doses. More importantly, 6-O-methyl-scutellarein (3) had better protective effects than scutellarin in rat cerebral ischemia. [ABSTRACT FROM AUTHOR]
- Subjects :
- NEURONS
ANALYSIS of variance
ANIMAL experimentation
ANTIOXIDANTS
BIOCHEMISTRY
CEREBRAL ischemia
FISHER exact test
HISTOLOGICAL techniques
NEUROLOGIC examination
NIMODIPINE
REPERFUSION
RESEARCH funding
SPACE perception
STATISTICS
DATA analysis
REPEATED measures design
DESCRIPTIVE statistics
FLAVONES
WOUNDS & injuries
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 20
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 134996059
- Full Text :
- https://doi.org/10.1080/10286020.2017.1383396