Novel findings from the multinational DOVE study on geographic and age‐related differences in pain perception and analgesic usage in children with sickle cell anaemia.

The article discusses the Determining Effects of Platelet Inhibition on Vaso-Occlusive Events (DOVE) study which assessed the potential efficacy of the antiplatelet agent, Prasugrel, to reduce veno-occlusive crisis (VOC). Topics include VOC as the primary reason that SCA patients seek medical care, way rates of pain and analgesic use were calculated for each participant, and identification of pre-adolescence as a transition point in chronic pain development.