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The control of antibody diversity during IgM and IgG anti-sheep red cell responses in mice.
- Source :
- Immunology; May84, Vol. 52 Issue 1, p97-105, 9p
- Publication Year :
- 1984
-
Abstract
- The isoelectric heterogeneity of both IgM and IgG murine anti-sheep red cell serum antibodies has been examined using an adaptation of published methods. It was found that the IgM spectra were restricted in a characteristic manner, implying oligoclonality. In cell transfer experiments, the T cell dependency of the IgM responses was confirmed. Further, helper cells appeared to switch on IgG antibody production and, simultaneously, recruit many novel IgG-forming clones into the response. The pattern of the IgM oligoclonality was attributed in part t o the inheritance of genes at, or closely linked to, the Ig1 heavy chain locus. These findings are discussed in relation to current research on the regulation of diversity. [ABSTRACT FROM AUTHOR]
- Subjects :
- IMMUNOGLOBULIN M
ERYTHROCYTES
CELL transformation
IMMUNOGLOBULIN G
ANTIGENS
SHEEP
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 52
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13506665