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High-risk type human papillomavirus infection and p16 expression in laryngeal cancer.
- Source :
- Infectious Agents & Cancer; 3/5/2019, Vol. 14 Issue 1, pN.PAG-N.PAG, 1p, 1 Color Photograph, 3 Charts, 1 Graph
- Publication Year :
- 2019
-
Abstract
- Background: Oropharyngeal cancers associated with high-risk type human papillomavirus (HR-HPV) infection have better prognosis than virus negative cancers. Similarly, the HPV status in laryngeal cancer (LC) may be associated with better outcome. Methods: Samples from 88 patients with LC were investigated using the polymerase chain reaction (PCR) and p16 immunohistochemistry for HR-HPV analysis. The cut-off point for p16 overexpression was diffuse (≥75%) tumor expression with at least moderate (+ 2/3) staining intensity. Results: The 5-year cumulative survival (CS) rate was 80.7% in all patients with LC. According to a combination of HR-HPV DNA status and p16 overexpression, subjects with LC were divided into four groups: HR-HPV DNA-positive/p16 overexpression-positive (n = 5, 5.7%; CS = 100%), HR-HPV DNA-positive/p16 overexpression-negative (n = 11, 12.5%; CS =81.8%), HR-HPV DNA-negative/p16 overexpression-positive (n = 0), and HR-HPV DNA-negative/p16 overexpression-negative (n = 72, 81.8%; CS = 79.5%). HR-HPV DNA-positive/p16-positive cases tended to have integrated HPV infection and high viral load, compared with HR-HPV DNA-positive/p16 overexpression-negative cases. Conclusions: LC patients with HPV infection and high levels of p16 expression might have an improved survival outcome; however, it is necessary to recruit additional LC cases with HPV infection to determine the definitive characteristics of HPV-mediated LC and estimate survival outcome. These results may contribute to the development of a useful method for selecting patients with a potentially fair response to treatment and ensure laryngeal preservation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17509378
- Volume :
- 14
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Infectious Agents & Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 135079318
- Full Text :
- https://doi.org/10.1186/s13027-019-0224-y