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Outbreak of myelocytomatosis caused by mutational avian leukosis virus subgroup J in China, 2018.
- Source :
- Transboundary & Emerging Diseases; Mar2019, Vol. 66 Issue 2, p622-626, 5p
- Publication Year :
- 2019
-
Abstract
- Avian leukosis virus subgroup J (ALV‐J) was isolated in meat‐type breeder chickens for the first time in 1988 in the United Kingdom. Due to the application of an eradication program, there were fewer reports related to myelocytomatosis or ALV‐J in China after 2013. However, there was another breakout almost simultaneously in six provinces of China in February 2018. On‐site, 15‐ to 20‐week‐old broiler breeder chickens showed depression, paralysis and weight loss. Mortality for certain flocks reached 15%. Sick chickens showed numerous yellow–white neoplasms growing in the sternum, rib and lumbar vertebra and had hepatic and renal metastasis. Histopathological observation showed all neoplasms were myelocytomas, and there were massive myelocyte‐like tumour cells in the liver, kidney and bone marrow. To explore the aetiology of this re‐outbreak of myelocytomatosis in China, we collected tumour‐bearing chickens and isolated six strains of ALV‐J (GM0209‐1 to ‐6). Phylogenetic analysis of gp85 and gp37 showed GM0209 strains were clearly distinct from the prototype strain of ADOL‐7501, HPRS‐103 and NX0101, and there was a mutation, R176G, in the conserved region between hr1 and hr2 regions of gp85, which was not found in other 44 ALV‐J strains. The 3′UTR nucleotide sequences of GM0209 isolates showed there was a signature deletion of 11 nt that was also present in 3′UTR sequences of SCDY1 and NHH, two isolates that have a reported association with haemangioma, indicating this deletion could not determine the tumour type induced by ALV‐J. Although the eradication program of ALV‐J has been successfully applied in China, the outbreak of ALV‐J still occurred, and the virus strain spread quickly. Thus, the biocharacteristics and pathogenesis of mutational ALV‐J should be further studied. [ABSTRACT FROM AUTHOR]
- Subjects :
- AVIAN leukosis
VIRUSES
POULTRY diseases
Subjects
Details
- Language :
- English
- ISSN :
- 18651674
- Volume :
- 66
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Transboundary & Emerging Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 135344628
- Full Text :
- https://doi.org/10.1111/tbed.13096